As of [update] , she was among the highest paid actresses in Taiwan. Shu ranked 18th on Forbes China Celebrity list in ,  23rd in ,  32nd in ,  48th in ,  and 90th in In , Shu starred in the French film The Transporter , the first installment of the Transporter franchise. This marked her first foray into the American market. Among Shu’s earlier notable works were The Foliage , a romance film set in Yunnan during the Cultural Revolution. The romantic comedy was the highest-grossing Chinese film of the year. The film overtook Lost in Thailand to become the highest-grossing Chinese movie. Shu reunited with Hou in his first wuxia film, The Assassin , starring as the title character.
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When cultivated under aeroponic growth conditions, Physalis crassifolia produced 11 new withanolides 1—11 and seven known withanolides 12—18 including those obtained from the wild-crafted plant. The structures of the new withanolides were elucidated by the application of spectroscopic techniques, and the known withanolides were identified by comparison of their spectroscopic data with those reported. Withanolides 1—11 and 16 were evaluated for their potential anticancer activity using five tumor cell lines.
The endophytic fungus Aspergillus austroafricanus isolated from leaves of the aquatic plant Eichhornia crassipes was fermented axenically on solid rice medium as well as in mixed cultures with Bacillus subtilis or with Streptomyces lividans. Austradixanthone 1 represents the first highly oxygenated heterodimeric xanthone derivative.
Abstract: Publication date: 1 October Source: Biochemical and Volume , Issue 4Author(s): Seung-Hoon Lee, Yeon-Ju Lee, Serk In Park, Jung-Eun Kim Chun-Chi Chen, Lilan Zhang, Weidong Liu, Shuyu Zhou, Jian Min, Shan Wu, Tatsuya Fukuta, Hirokazu Yamamoto, Mitsuaki Yanagida, Miki Honda, Naoto.
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Table of Contents
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Genome Research (IF ) Pub Date: , DOI: /gr. Jordan A. Ramilowski; Chi Wai Yip; Saumya Agrawal; Jen-Chien Chang; Yari Ciani; Ivan V. Kulakovskiy; Mickaël Mendez; Jasmine Li Ching Ooi; John F. Claudio Schneider; Harukazu Suzuki; Ken Yagi; Michiel J.L. de Hoon; Jay W.
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Long noncoding RNAs lncRNAs constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Article published online before print.
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Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo-box domain PBD present in the C-terminal non-catalytic region of polo kinases plays a pivotal role in the function of these enzymes. Recent advances in our comprehension of the mechanisms underlying mammalian polo-like kinase 1 Plk1 -dependent protein—protein interactions revealed that the PBD serves as an essential molecular mediator that brings the kinase domain of Plk1 into proximity with its substrates, mainly through phospho-dependent interactions with its target proteins.
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Polo-box domain: a versatile mediator of polo-like kinase function
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Optical sensing is becoming the dominant type of sensor, partly because of the incredible versatility of optical methods and partly because of the emergence of new optical materials whose properties respond to interactions with molecular species. The vast majority of these materials are either 2D nanomaterials such as graphene or 3D nanomaterials such as quantum dots. These new optical-transducers enable ultrasensitive responses, the capability of single molecule detection, the ability to operate within confined environments such as inside cells or to provide in vivo analytical information whilst being interrogated from outside the body.
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During cytokinesis, a specialized set of proteins is recruited to the equatorial region between spindle poles by microtubules and actin filaments, enabling furrow assembly and ingression before cell division. We investigate the mechanisms underlying regional specialization of the cytoskeleton in HeLa cells undergoing drug-synchronized monopolar cytokinesis.
After forced mitotic exit, the cytoskeleton of monopolar mitotic cells is initially radially symmetric but undergoes a symmetry-breaking reaction that simultaneously polarizes microtubules and the cell cortex, with a concentration of cortical furrow markers into a cap at one side of the cell. Aurora B localizes to actin cables in a gap between the monopolar midzone and the furrow-like cortex, suggesting a communication between them.
We propose that feedback loops between cortical furrow components and microtubules promote symmetry breaking during monopolar cytokinesis and regional specialization of the cytoskeleton during normal bipolar cytokinesis.
Seong YS, Kamijo K, Lee JS, Fernandez E, Kuriyama R, Miki T, Lee KS Young H. Kang;, Kyung H. Lee;, Chi Hoon Park; & Kyung S. Lee.
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